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KMID : 0043319990220040401
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Archives of Pharmacal Research
1999 Volume.22 No. 4 p.401 ~ p.403
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Anti-Platelet Aggregation Activity of Stilbene Derivatives from Rheum undulatum
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Ko Sung-Kwon
Lee Seung-Mok
Whang Wan Kyunn
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Abstract
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In continued studies on cultivated Korean rhubarb rhizomes (Rheum undulatum), three known stillbenes (desoxyrhapontigenin, rhapontigenin, piceatannol) have been screened for activity on blood platelet aggregation. Both rhapontigenin and desoxyrhapontigenin exhibited strong inhibition on the aggregation induced by arachidonic acid collagen. However, piceatannol did not show inhibition. These inhibitory effects may partially contribute to anti-blood stagnancy activity of rhubarb.
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KEYWORD
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Platelet aggregation, Rheum undulatum, Cultivated Korean rhubarb rhizomes, Stillbenes, Desoxyrhapontigenin, Rhapontigenin, Piceatannol
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